Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis

Increased Src activity has been associated with the pathogenesis of renal tumors and some glomerular diseases, but its role in renal interstitial fibrosis remains elusive. To evaluate this, cultured renal interstitial fibroblasts (NRK-49F) were treated with PP1, a selective inhibitor of Src. This re...

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Bibliografiska uppgifter
I publikationen:Kidney Int
Huvudupphovsmän: Yan, Yanli, Ma, Li, Zhou, Xiaoxu, Ponnusamy, Murugavel, Tang, Jinhua, Zhuang, Michelle A., Tolbert, Evelyn, Bayliss, Georgia, Bai, Jianwen, Zhuang, Shougang
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824676/
https://ncbi.nlm.nih.gov/pubmed/26444028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2015.293
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