Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis

Increased Src activity has been associated with the pathogenesis of renal tumors and some glomerular diseases, but its role in renal interstitial fibrosis remains elusive. To evaluate this, cultured renal interstitial fibroblasts (NRK-49F) were treated with PP1, a selective inhibitor of Src. This re...

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Veröffentlicht in:Kidney Int
Hauptverfasser: Yan, Yanli, Ma, Li, Zhou, Xiaoxu, Ponnusamy, Murugavel, Tang, Jinhua, Zhuang, Michelle A., Tolbert, Evelyn, Bayliss, Georgia, Bai, Jianwen, Zhuang, Shougang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824676/
https://ncbi.nlm.nih.gov/pubmed/26444028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2015.293
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