Blocking the Class I Histone Deacetylase Ameliorates Renal Fibrosis and Inhibits Renal Fibroblast Activation via Modulating TGF-Beta and EGFR Signaling

BACKGROUND: Histone deacetylase (HDAC) inhibitors are promising anti-fibrosis drugs; however, nonselective inhibition of class I and class II HDACs does not allow a detailed elucidation of the individual HDAC functions in renal fibrosis. In this study, we investigated the effect of MS-275, a selecti...

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Bibliografiske detaljer
Main Authors: Liu, Na, He, Song, Ma, Li, Ponnusamy, Murugavel, Tang, Jinhua, Tolbert, Evelyn, Bayliss, George, Zhao, Ting C., Yan, Haidong, Zhuang, Shougang
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546966/
https://ncbi.nlm.nih.gov/pubmed/23342059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054001
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