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Activation of Sirtuin-1 Promotes Renal Fibroblast Activation and Aggravates Renal Fibrogenesis

Although activation of sirtuin-1 (SIRT1) has been shown to protect the kidney from acute injury, its role in renal fibrosis remains controversial since both inhibition and activation of SIRT1 have been reported to attenuate renal fibrosis. To resolve this conflict, we further examined the effect of...

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Bibliografiske detaljer
Udgivet i:J Pharmacol Exp Ther
Main Authors: Ponnusamy, Murugavel, Zhuang, Michelle A., Zhou, Xiaoxu, Tolbert, Evelyn, Bayliss, George, Zhao, Ting C., Zhuang, Shougang
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518074/
https://ncbi.nlm.nih.gov/pubmed/26022003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.224386
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