Immunopurification of Pathological Prion Protein Aggregates

BACKGROUND: Prion diseases are fatal neurodegenerative disorders that can arise sporadically, be genetically inherited or acquired through infection. The key event in these diseases is misfolding of the cellular prion protein (PrP(C)) into a pathogenic isoform that is rich in β-sheet structure. This...

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Bibliographische Detailangaben
Hauptverfasser: Biasini, Emiliano, Tapella, Laura, Mantovani, Susanna, Stravalaci, Matteo, Gobbi, Marco, Harris, David A., Chiesa, Roberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773113/
https://ncbi.nlm.nih.gov/pubmed/19915706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007816
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