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5-Azacytidine Can Induce Lethal Mutagenesis in Human Immunodeficiency Virus Type 1

Ribonucleosides inhibit human immunodeficiency virus type 1 (HIV-1) replication by mechanisms that have not been fully elucidated. Here, we report the antiviral mechanism for the ribonucleoside analog 5-azacytidine (5-AZC). We hypothesized that the anti-HIV-1 activity of 5-AZC was due to an increase...

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Detalhes bibliográficos
Main Authors: Dapp, Michael J., Clouser, Christine L., Patterson, Steven, Mansky, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772699/
https://ncbi.nlm.nih.gov/pubmed/19726509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01406-09
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