5-Azacytidine Enhances the Mutagenesis of HIV-1 by Reduction to 5-Aza-2′-Deoxycytidine

5-Azacytidine (5-aza-C) is a ribonucleoside analog that induces the lethal mutagenesis of human immunodeficiency virus type 1 (HIV-1) by causing predominantly G-to-C transversions during reverse transcription. 5-Aza-C could potentially act primarily as a ribonucleotide (5-aza-CTP) or as a deoxyribon...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Rawson, Jonathan M. O., Daly, Michele B., Xie, Jiashu, Clouser, Christine L., Landman, Sean R., Reilly, Cavan S., Bonnac, Laurent, Kim, Baek, Patterson, Steven E., Mansky, Louis M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808159/
https://ncbi.nlm.nih.gov/pubmed/26833151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03084-15
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