5,6-Dihydro-5-aza-2’-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors

The nucleoside analog 5,6-dihydro-5-aza-2’-deoxycytidine (KP-1212) has been investigated as a first-in-class lethal mutagen of human immunodeficiency virus type-1 (HIV-1). Since a prodrug monotherapy did not reduce viral loads in Phase II clinical trials, we tested if ribonucleotide reductase inhibi...

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Detalhes bibliográficos
Main Authors: Rawson, Jonathan M., Heineman, Richard H., Beach, Lauren B., Martin, Jessica L., Schnettler, Erica K., Dapp, Michael J., Patterson, Steven E., Mansky, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930610/
https://ncbi.nlm.nih.gov/pubmed/24120088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.08.023
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