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5-aza-2′,2′-Difluroro Deoxycytidine (NUC013): A Novel Nucleoside DNA Methyl Transferase Inhibitor and Ribonucleotide Reductase Inhibitor for the Treatment of Cancer

Tumor suppressor genes can be silenced genetically as well as epigenetically. One approach to reversing epigenetic suppression of tumor suppressor genes is to inhibit DNA methyl transferase. 5-aza-2′,2′-diflurorodeoxycytidine (NUC013) is a novel DNA methyl transferase and ribonucleotide reductase in...

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Dades bibliogràfiques
Publicat a:Pharmaceuticals (Basel)
Autors principals: Daifuku, Richard, Hu, Zhenbo, Saunthararajah, Yogen
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620609/
https://ncbi.nlm.nih.gov/pubmed/28726739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph10030065
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