Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4′-thio-2′-deoxycytidine and 5-aza-4′-thio-2′-deoxycytidine

PURPOSE: Currently approved DNA hypomethylating nucleosides elicit their effects in part by depleting DNA methyltransferase I (DNMT1). However, their low response rates and adverse effects continue to drive the discovery of newer DNMT1 depleting agents. Herein, we identified two novel 2′-deoxycytidi...

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Main Authors: Thottassery, Jaideep V., Sambandam, Vijaya, Allan, Paula W., Maddry, Joseph A., Maxuitenko, Yulia Y., Tiwari, Kamal, Hollingshead, Melinda, Parker, William B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194194/
https://ncbi.nlm.nih.gov/pubmed/24908436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2503-z
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