5-Aza-2′-deoxycytidine-induced genome rearrangements are mediated by DNMT1

Observations that genome-wide DNA hypomethylation induces genomic instability and tumors in animals caution against the indiscriminate use of demethylating agents, such as 5-aza-2′-deoxycytidine (5-Aza-dC). Using primary mouse embryonic fibroblasts harboring a lacZ mutational reporter construct that...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Maslov, Alexander Y., Lee, Moonsook, Gundry, Michael, Gravina, Silvia, Strogonova, Nadezhda, Tazearslan, Cagdas, Bendebury, Anastasia, Suh, Yousin, Vijg, Jan
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381073/
https://ncbi.nlm.nih.gov/pubmed/22349820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.9
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars