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5-Aza-2′-deoxycytidine-induced genome rearrangements are mediated by DNMT1
Observations that genome-wide DNA hypomethylation induces genomic instability and tumors in animals caution against the indiscriminate use of demethylating agents, such as 5-aza-2′-deoxycytidine (5-Aza-dC). Using primary mouse embryonic fibroblasts harboring a lacZ mutational reporter construct that...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3381073/ https://ncbi.nlm.nih.gov/pubmed/22349820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.9 |
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