Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine

Vitamin C deficiency is found in patients with cancer and might complicate various therapy paradigms. Here we show how this deficiency may influence the use of DNA methyltransferase inhibitors (DNMTis) for treatment of hematological neoplasias. In vitro, when vitamin C is added at physiological leve...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liu, Minmin, Ohtani, Hitoshi, Zhou, Wanding, Ørskov, Andreas Due, Charlet, Jessica, Zhang, Yang W., Shen, Hui, Baylin, Stephen B., Liang, Gangning, Grønbæk, Kirsten, Jones, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027469/
https://ncbi.nlm.nih.gov/pubmed/27573823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612262113
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