Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine

Vitamin C deficiency is found in patients with cancer and might complicate various therapy paradigms. Here we show how this deficiency may influence the use of DNA methyltransferase inhibitors (DNMTis) for treatment of hematological neoplasias. In vitro, when vitamin C is added at physiological leve...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Liu, Minmin, Ohtani, Hitoshi, Zhou, Wanding, Ørskov, Andreas Due, Charlet, Jessica, Zhang, Yang W., Shen, Hui, Baylin, Stephen B., Liang, Gangning, Grønbæk, Kirsten, Jones, Peter A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027469/
https://ncbi.nlm.nih.gov/pubmed/27573823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612262113
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