Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine

Vitamin C deficiency is found in patients with cancer and might complicate various therapy paradigms. Here we show how this deficiency may influence the use of DNA methyltransferase inhibitors (DNMTis) for treatment of hematological neoplasias. In vitro, when vitamin C is added at physiological leve...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Liu, Minmin, Ohtani, Hitoshi, Zhou, Wanding, Ørskov, Andreas Due, Charlet, Jessica, Zhang, Yang W., Shen, Hui, Baylin, Stephen B., Liang, Gangning, Grønbæk, Kirsten, Jones, Peter A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027469/
https://ncbi.nlm.nih.gov/pubmed/27573823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612262113
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