Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine

Vitamin C deficiency is found in patients with cancer and might complicate various therapy paradigms. Here we show how this deficiency may influence the use of DNA methyltransferase inhibitors (DNMTis) for treatment of hematological neoplasias. In vitro, when vitamin C is added at physiological leve...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Liu, Minmin, Ohtani, Hitoshi, Zhou, Wanding, Ørskov, Andreas Due, Charlet, Jessica, Zhang, Yang W., Shen, Hui, Baylin, Stephen B., Liang, Gangning, Grønbæk, Kirsten, Jones, Peter A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2016
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027469/
https://ncbi.nlm.nih.gov/pubmed/27573823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612262113
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