Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2′-deoxycytidine

Viral lethal mutagenesis is a strategy whereby the innate immune system or mutagenic pool nucleotides increase the error rate of viral replication above the error catastrophe limit. Lethal mutagenesis has been proposed as a mechanism for several antiviral compounds, including the drug candidate 5-az...

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Bibliographic Details
Main Authors: Li, Deyu, Fedeles, Bogdan I., Singh, Vipender, Peng, Chunte Sam, Silvestre, Katherine J., Simi, Allison K., Simpson, Jeffrey H., Tokmakoff, Andrei, Essigmann, John M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136561/
https://ncbi.nlm.nih.gov/pubmed/25071207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405635111
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