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A Ca(2+)-Sensing Molecular Switch Based on Alternate Frame Protein Folding
Existing strategies for creating biosensors mainly rely on large conformational changes to transduce a binding event to an output signal. Most molecules, however, do not exhibit large-scale structural changes upon substrate binding. Here, we present a general approach (alternate frame folding, or AF...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2769504/ https://ncbi.nlm.nih.gov/pubmed/18947182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb800177f |
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