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Structural Characterization of Two Alternate Conformations in a Calbindin D(9k)-Based Molecular Switch
[Image: see text] We have demonstrated that calbindin D(9k) can be converted into a calcium-sensing switch (calbindin-AFF) by duplicating the C-terminal half of the protein (residues 44–75) and appending it to the N-terminus (creating residues 44′–75′). This re-engineering results in a ligand-driven...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3140711/ https://ncbi.nlm.nih.gov/pubmed/21618991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi102040g |
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