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Structural Characterization of Two Alternate Conformations in a Calbindin D(9k)-Based Molecular Switch

[Image: see text] We have demonstrated that calbindin D(9k) can be converted into a calcium-sensing switch (calbindin-AFF) by duplicating the C-terminal half of the protein (residues 44–75) and appending it to the N-terminus (creating residues 44′–75′). This re-engineering results in a ligand-driven...

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Bibliographic Details
Main Authors: Stratton, Margaret M., McClendon, Sebastian, Eliezer, David, Loh, Stewart N.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140711/
https://ncbi.nlm.nih.gov/pubmed/21618991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi102040g
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