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On the mechanism of protein fold-switching by a molecular sensor
Alternate frame folding (AFF) is a mechanism by which conformational change can be engineered into a protein. The protein structure switches from the wild-type fold (N) to a circularly-permuted fold (N′), or vice versa, in response to a signaling event such as ligand binding. Despite the fact that t...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3145374/ https://ncbi.nlm.nih.gov/pubmed/20806404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22833 |
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