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Species-Specific Differences in Translational Regulation of Dihydrofolate Reductase
We have observed that rodent cell lines (mouse, hamster) contain approximately 10 times the levels of dihydrofolate reductase as human cell lines, yet the sensitivity to methotrexate (ED(50)), the folate antagonist that targets this enzyme, is similar. Our previous studies showed that dihydrofolate...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Pharmacology and Experimental Therapeutics
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2769051/ https://ncbi.nlm.nih.gov/pubmed/19570950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.055772 |
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