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A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance
MicroRNAs are predicted to regulate ≈30% of all human genes by targeting sequences in their 3′ UTR. Polymorphisms in 3′ UTR of several genes have been reported to affect gene expression, but the mechanism is not fully understood. Here, we demonstrate that 829C→T, a naturally occurring SNP, near the...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1948927/ https://ncbi.nlm.nih.gov/pubmed/17686970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706217104 |
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