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A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance

MicroRNAs are predicted to regulate ≈30% of all human genes by targeting sequences in their 3′ UTR. Polymorphisms in 3′ UTR of several genes have been reported to affect gene expression, but the mechanism is not fully understood. Here, we demonstrate that 829C→T, a naturally occurring SNP, near the...

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Detalhes bibliográficos
Main Authors: Mishra, Prasun J., Humeniuk, Rita, Mishra, Pravin J., Longo-Sorbello, Giuseppe S. A., Banerjee, Debabrata, Bertino, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948927/
https://ncbi.nlm.nih.gov/pubmed/17686970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706217104
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