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A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance

MicroRNAs are predicted to regulate ≈30% of all human genes by targeting sequences in their 3′ UTR. Polymorphisms in 3′ UTR of several genes have been reported to affect gene expression, but the mechanism is not fully understood. Here, we demonstrate that 829C→T, a naturally occurring SNP, near the...

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Bibliografische gegevens
Hoofdauteurs: Mishra, Prasun J., Humeniuk, Rita, Mishra, Pravin J., Longo-Sorbello, Giuseppe S. A., Banerjee, Debabrata, Bertino, Joseph R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948927/
https://ncbi.nlm.nih.gov/pubmed/17686970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706217104
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