A second target of benzamide riboside: Dihydrofolate reductase

Dihydrofolate reductase (DHFR) is an essential enzyme involved in de novo purine and thymidine biosynthesis. For several decades, selective inhibition of DHFR has proven to be a potent therapeutic approach in the treatment of various cancers including acute lymphoblastic leukemia, non-Hodgkin’s lymp...

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Autors principals: Roussel, Breton, Johnson-Farley, Nadine, Kerrigan, John E., Scotto, Kathleen W., Banerjee, Debabrata, Felczak, Krzysztof, Pankiewicz, Krzysztof W., Gounder, Murugesan, Lin, HongXia, Abali, Emine Ercikan, Bertino, Joseph R.
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2012
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493437/
https://ncbi.nlm.nih.gov/pubmed/22954684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.21786
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