Enhanced Degradation of Dihydrofolate Reductase through Inhibition of NAD Kinase by Nicotinamide Analogs

Dihydrofolate reductase (DHFR), because of its essential role in DNA synthesis, has been targeted for the treatment of a wide variety of human diseases, including cancer, autoimmune diseases, and infectious diseases. Methotrexate (MTX), a tight binding inhibitor of DHFR, is one of the most widely us...

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Main Authors: Hsieh, Yi-Ching, Tedeschi, Philip, AdeBisi Lawal, Rialnat, Banerjee, Debabrata, Scotto, Kathleen, Kerrigan, John E., Lee, Kuo-Chieh, Johnson-Farley, Nadine, Bertino, Joseph R., Abali, Emine Ercikan
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558814/
https://ncbi.nlm.nih.gov/pubmed/23197646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.080218
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