Enhanced Degradation of Dihydrofolate Reductase through Inhibition of NAD Kinase by Nicotinamide Analogs

Dihydrofolate reductase (DHFR), because of its essential role in DNA synthesis, has been targeted for the treatment of a wide variety of human diseases, including cancer, autoimmune diseases, and infectious diseases. Methotrexate (MTX), a tight binding inhibitor of DHFR, is one of the most widely us...

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Bibliografiske detaljer
Main Authors: Hsieh, Yi-Ching, Tedeschi, Philip, AdeBisi Lawal, Rialnat, Banerjee, Debabrata, Scotto, Kathleen, Kerrigan, John E., Lee, Kuo-Chieh, Johnson-Farley, Nadine, Bertino, Joseph R., Abali, Emine Ercikan
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2013
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558814/
https://ncbi.nlm.nih.gov/pubmed/23197646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.080218
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