GENE TRANSFER OF INDUCIBLE NITRIC OXIDE SYNTHASE AFFORDS CARDIOPROTECTION BY UPREGULATING HEME OXYGENASE-1 VIA AN NF-κB-DEPENDENT PATHWAY

BACKGROUND: Although inducible nitric oxide synthase (iNOS) is known to impart powerful protection against myocardial infarction, the mechanism for this salubrious action remains unclear. METHODS AND RESULTS: Adenovirus-mediated iNOS gene transfer in mice resulted, 48-72 h later, in increased expres...

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Detalhes bibliográficos
Main Authors: Li, Qianhong, Guo, Yiru, Ou, Qinghui, Cui, Chuanjue, Wu, Wen-Jian, Tan, Wei, Zhu, Xiaoping, Lanceta, Lilibeth B, Sanganalmath, Santosh K., Dawn, Buddhadeb, Shinmura, Ken, Rokosh, Gregg D., Wang, Shuyan, Bolli, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768612/
https://ncbi.nlm.nih.gov/pubmed/19752329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.778688
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