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GENE TRANSFER OF INDUCIBLE NITRIC OXIDE SYNTHASE AFFORDS CARDIOPROTECTION BY UPREGULATING HEME OXYGENASE-1 VIA AN NF-κB-DEPENDENT PATHWAY
BACKGROUND: Although inducible nitric oxide synthase (iNOS) is known to impart powerful protection against myocardial infarction, the mechanism for this salubrious action remains unclear. METHODS AND RESULTS: Adenovirus-mediated iNOS gene transfer in mice resulted, 48-72 h later, in increased expres...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2768612/ https://ncbi.nlm.nih.gov/pubmed/19752329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.778688 |
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