Gene transfer as a strategy to achieve permanent cardioprotection II: rAAV-mediated gene therapy with heme oxygenase-1 limits infarct size 1 year later without adverse functional consequences

Extensive evidence indicates that heme oxygenase-1 (HO-1) exerts potent cytoprotective effects in response to stress. Previous studies have shown that gene therapy with HO-1 protects against myocardial ischemia/reperfusion injury for up to 8 weeks after gene transfer. However, the long-term effects...

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Detalhes bibliográficos
Main Authors: Li, Qianhong, Guo, Yiru, Ou, Qinghui, Wu, Wen-Jian, Chen, Ning, Zhu, Xiaoping, Tan, Wei, Yuan, Fangping, Dawn, Buddhadeb, Luo, Li, Hunt, Gregory N., Bolli, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640464/
https://ncbi.nlm.nih.gov/pubmed/21785893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-011-0208-6
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