Gene transfer as a strategy to achieve permanent cardioprotection I: rAAV-mediated gene therapy with inducible nitric oxide synthase limits infarct size 1 year later without adverse functional consequences

The ultimate goal of prophylactic gene therapy is to confer permanent protection against ischemia. Although gene therapy with inducible nitric oxide synthase (iNOS) is known to protect against myocardial infarction at 3 days and up to 2 months, the long-term effects on myocardial ischemic injury and...

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Detalhes bibliográficos
Main Authors: Li, Qianhong, Guo, Yiru, Wu, Wen-Jian, Ou, Qinghui, Zhu, Xiaoping, Tan, Wei, Yuan, Fangping, Chen, Ning, Dawn, Buddhadeb, Luo, Li, O’Brien, Erin, Bolli, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640477/
https://ncbi.nlm.nih.gov/pubmed/21779912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-011-0207-7
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