Cardioprotection Afforded by Inducible Nitric Oxide Synthase Gene Therapy Is Mediated by Cyclooxygenase-2 via a Nuclear Factor-κB–Dependent Pathway

BACKGROUND: Gene therapy with inducible nitric oxide synthase (iNOS) markedly reduces myocardial infarct size; this effect is associated with cyclooxygenase-2 (COX-2) upregulation and is ablated by COX-2 inhibitors. However, pharmacological inhibitors are limited by relative lack of specificity; fur...

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Bibliographic Details
Main Authors: Li, Qianhong, Guo, Yiru, Tan, Wei, Ou, Qinghui, Wu, Wen-Jian, Sturza, Diana, Dawn, Buddhadeb, Hunt, Greg, Cui, Chuanjue, Bolli, Roberto
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654387/
https://ncbi.nlm.nih.gov/pubmed/17785622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.107.689810
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