Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys

Striatal neurons convert l-dopa to dopamine (DA) following gene transfer of aromatic l-amino acid decarboxylase (AADC) via adeno-associated virus (AAV) in parkinsonian monkeys. We investigated whether AAV-AADC could reduce or eliminate l-dopa-induced dyskinesias (LIDs) and side effects in MPTP-treat...

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Main Authors: Bankiewicz, Krystof S., Daadi, Marcel, Pivirotto, Philip, Bringas, John, Sanftner, Laura, Cunningham, Janet, Forsayeth, John R., Eberling, Jamie L.
格式: Artigo
語言:Inglês
出版: 2005
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766604/
https://ncbi.nlm.nih.gov/pubmed/16337943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2005.10.022
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