Splice Site Strength-Dependent Activity and Genetic Buffering by Poly-G Runs

Pre-mRNA splicing is regulated through combinatorial activity of RNA motifs including splice sites and splicing regulatory elements (SREs). Here, we show that the activity of the G-run class of SREs is ∼4-fold higher when adjacent to intermediate strength 5'ss relative to weak 5'ss, and ∼1...

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Bibliografiske detaljer
Main Authors: Xiao, Xinshu, Wang, Zefeng, Jang, Minyoung, Nutiu, Razvan, Wang, Eric T., Burge, Christopher B.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766517/
https://ncbi.nlm.nih.gov/pubmed/19749754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1661
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