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Splice Site Strength-Dependent Activity and Genetic Buffering by Poly-G Runs
Pre-mRNA splicing is regulated through combinatorial activity of RNA motifs including splice sites and splicing regulatory elements (SREs). Here, we show that the activity of the G-run class of SREs is ∼4-fold higher when adjacent to intermediate strength 5'ss relative to weak 5'ss, and ∼1...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2766517/ https://ncbi.nlm.nih.gov/pubmed/19749754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1661 |
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