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Histone deacetylase inhibitor selectively induces p21(WAF1) expression and gene-associated histone acetylation

Histone deacetylases (HDACs) catalyze the removal of acetyl groups on the amino-terminal lysine residues of core nucleosomal histones. This activity is associated generally with transcriptional repression. We have reported previously that inhibition of HDAC activity by hydroxamic acid-based hybrid p...

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書誌詳細
主要な著者: Richon, Victoria M., Sandhoff, Todd W., Rifkind, Richard A., Marks, Paul A.
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 2000
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC27656/
https://ncbi.nlm.nih.gov/pubmed/10954755
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