Histone deacetylase (HDAC) inhibitor activation of p21(WAF1) involves changes in promoter-associated proteins, including HDAC1

Histone deacetylase (HDAC) inhibitors (HDACi) cause cancer cell growth arrest and/or apoptosis in vivo and in vitro. The HDACi suberoylanilide hydroxamic acid (SAHA) is in phase I/II clinical trials showing significant anticancer activity. Despite wide distribution of HDACs in chromatin, SAHA alters...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Gui, C.-Y., Ngo, L., Xu, W. S., Richon, V. M., Marks, P. A.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2004
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC337037/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14734806/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307708100
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