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Histone deacetylase (HDAC) inhibitor activation of p21(WAF1) involves changes in promoter-associated proteins, including HDAC1
Histone deacetylase (HDAC) inhibitors (HDACi) cause cancer cell growth arrest and/or apoptosis in vivo and in vitro. The HDACi suberoylanilide hydroxamic acid (SAHA) is in phase I/II clinical trials showing significant anticancer activity. Despite wide distribution of HDACs in chromatin, SAHA alters...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC337037/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14734806/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307708100 |
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