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Histone deacetylase (HDAC) inhibitor activation of p21(WAF1) involves changes in promoter-associated proteins, including HDAC1
Histone deacetylase (HDAC) inhibitors (HDACi) cause cancer cell growth arrest and/or apoptosis in vivo and in vitro. The HDACi suberoylanilide hydroxamic acid (SAHA) is in phase I/II clinical trials showing significant anticancer activity. Despite wide distribution of HDACs in chromatin, SAHA alters...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC337037/ https://ncbi.nlm.nih.gov/pubmed/14734806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307708100 |
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