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Histone deacetylase inhibitor selectively induces p21(WAF1) expression and gene-associated histone acetylation

Histone deacetylases (HDACs) catalyze the removal of acetyl groups on the amino-terminal lysine residues of core nucleosomal histones. This activity is associated generally with transcriptional repression. We have reported previously that inhibition of HDAC activity by hydroxamic acid-based hybrid p...

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Detalhes bibliográficos
Main Authors: Richon, Victoria M., Sandhoff, Todd W., Rifkind, Richard A., Marks, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC27656/
https://ncbi.nlm.nih.gov/pubmed/10954755
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