Acetylation of p53 at Lysine 373/382 by the Histone Deacetylase Inhibitor Depsipeptide Induces Expression of p21(Waf1/Cip1)

Generally, histone deacetylase (HDAC) inhibitor-induced p21(Waf1/Cip1) expression is thought to be p53 independent. Here we found that an inhibitor of HDAC, depsipeptide (FR901228), but not trichostatin A (TSA), induces p21(Waf1/Cip1) expression through both p53 and Sp1/Sp3 pathways in A549 cells (w...

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Bibliographic Details
Main Authors: Zhao, Ying, Lu, Shaoli, Wu, Lipeng, Chai, Guolin, Wang, Haiying, Chen, Yingqi, Sun, Jia, Yu, Yu, Zhou, Wen, Zheng, Quanhui, Wu, Mian, Otterson, Gregory A., Zhu, Wei-Guo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430330/
https://ncbi.nlm.nih.gov/pubmed/16537920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.7.2782-2790.2006
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