Histone deacetylase inhibitor selectively induces p21(WAF1) expression and gene-associated histone acetylation

Histone deacetylases (HDACs) catalyze the removal of acetyl groups on the amino-terminal lysine residues of core nucleosomal histones. This activity is associated generally with transcriptional repression. We have reported previously that inhibition of HDAC activity by hydroxamic acid-based hybrid p...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Richon, Victoria M., Sandhoff, Todd W., Rifkind, Richard A., Marks, Paul A.
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 2000
主題:	Biological Sciences
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27656/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10954755/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.180316197
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