Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

The α-ketoglutarate-dependent hydroxylases and halogenases employ similar reaction mechanisms involving hydrogen-abstracting Fe(IV)-oxo (ferryl) intermediates. In the halogenases, the carboxylate residue from the His(2)(Asp/Glu)(1)“facial triad” of iron ligands found in the hydroxylases is replaced...

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Main Authors: Matthews, Megan L., Neumann, Christopher S., Miles, Linde A., Grove, Tyler L., Booker, Squire J., Krebs, Carsten, Walsh, Christopher T., Bollinger, J. Martin
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764930/
https://ncbi.nlm.nih.gov/pubmed/19815524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909649106
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