Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

The α-ketoglutarate-dependent hydroxylases and halogenases employ similar reaction mechanisms involving hydrogen-abstracting Fe(IV)-oxo (ferryl) intermediates. In the halogenases, the carboxylate residue from the His(2)(Asp/Glu)(1)“facial triad” of iron ligands found in the hydroxylases is replaced...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Matthews, Megan L., Neumann, Christopher S., Miles, Linde A., Grove, Tyler L., Booker, Squire J., Krebs, Carsten, Walsh, Christopher T., Bollinger, J. Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764930/
https://ncbi.nlm.nih.gov/pubmed/19815524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909649106
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares