Mass Spectrometric Analysis of a Cyclic 7,8-Butanoguanine Adduct of N-Nitrosopyrrolidine: Comparison to other N-Nitrosopyrrolidine Adducts in Rat Hepatic DNA

The well established rat hepatocarcinogen N-nitrosopyrrolidine (NPYR, 1) requires metabolic activation to DNA adducts to express its carcinogenic activity. Among the NPYR-DNA adducts that have been identified, the cyclic 7,8-butanoguanine adduct 2-amino-6,7,8,9-tetrahydro-9-hydroxypyrido[2,1-f]purin...

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Detalhes bibliográficos
Main Authors: Loureiro, Ana Paula M., Zhang, Wenbing, Kassie, Fekadu, Zhang, Siyi, Villalta, Peter W., Wang, Mingyao, Hecht, Stephen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763979/
https://ncbi.nlm.nih.gov/pubmed/19761253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900238t
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