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Analysis of Pyridyloxobutyl DNA Adducts in F344 Rats Chronically Treated with (R)- and (S)- N′-Nitrosonornicotine
NNN (1) is an esophageal carcinogen in rats. 2′-Hydroxylation of NNN is believed to be the major bioactivation pathway for NNN tumorigenicity. (S)-NNN is preferentially metabolized by 2′-hydroxylation in cultured rat esophagus, while there is no preference for 2′-hydroxylation vs. 5′-hydroxylation i...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518847/ https://ncbi.nlm.nih.gov/pubmed/17305408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx060208j |
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