Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N´-Nitrosonornicotine

The tobacco-specific carcinogens N´-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity. NNN and NNK are metabolized to the same reactive diazonium ions, which alkylate DNA forming pyridyloxobutyl (POB) DNA bas...

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Publicado en:Chem Res Toxicol
Autores principales: Li, Yupeng, Ma, Bin, Cao, Qing, Balbo, Silvia, Zhao, Lijiao, Upadhyaya, Pramod, Hecht, Stephen S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6790228/
https://ncbi.nlm.nih.gov/pubmed/30740971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00007
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