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Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N´-Nitrosonornicotine
The tobacco-specific carcinogens N´-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity. NNN and NNK are metabolized to the same reactive diazonium ions, which alkylate DNA forming pyridyloxobutyl (POB) DNA bas...
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| Publicado no: | Chem Res Toxicol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6790228/ https://ncbi.nlm.nih.gov/pubmed/30740971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00007 |
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