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Quantitation of pyridyloxobutyl-DNA adducts in tissues of rats treated chronically with (R)- or (S)-N’-nitrosonornicotine (NNN) in a carcinogenicity study

We quantified DNA adducts resulting from 2’-hydroxylation of enantiomers of the tobacco-specific nitrosamine N’-nitrosonornicotine (NNN) in tissues of male F-344 rats after 10, 30, 50, and 70 weeks of treatment with 14 ppm in the drinking water. These rats were in subgroups of a carcinogenicity stud...

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Main Authors: Zhao, Lijiao, Balbo, Silvia, Wang, Mingyao, Upadhyaya, Pramod, Khariwala, Samir S., Villalta, Peter W., Hecht, Stephen S.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848204/
https://ncbi.nlm.nih.gov/pubmed/24001146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400235x
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