Identification of Adducts Formed in the Reaction of α-Acetoxy-N-Nitrosopyrrolidine with Deoxyribonucleosides and DNA

N-Nitrosopyrrolidine (NPYR) is a well-established hepatocarcinogen in the rat. NPYR requires metabolic activation by cytochrome P450-catalyzed α-hydroxylation to express its carcinogenic activity. This produces α-hydroxyNPYR (2) which spontaneously ring opens to 4-oxobutanediazohydroxide (4), a high...

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Hlavní autoři: Wang, Mingyao, Lao, Yanbin, Cheng, Guang, Shi, Yongli, Villalta, Peter W., Hecht, Stephen S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518840/
https://ncbi.nlm.nih.gov/pubmed/17394360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx600332p
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