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Analysis of Adducts in Hepatic DNA of Rats Treated with N-Nitrosopyrrolidine

N-Nitrosopyrrolidine (NPYR) is a hepatocarcinogen in rats. It is metabolically activated by cytochrome P450 enzymes in the liver leading to the formation of 4-oxobutanediazohydroxide (4) and related intermediates that react with DNA to form adducts. Since DNA adducts are thought to be critical in ca...

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Detalhes bibliográficos
Principais autores: Wang, Mingyao, Lao, Yanbin, Cheng, Guang, Shi, Yongli, Villalta, Peter W., Nishikawa, Akiyoshi, Hecht, Stephen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518975/
https://ncbi.nlm.nih.gov/pubmed/17394361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx600333e
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