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Analysis of Adducts in Hepatic DNA of Rats Treated with N-Nitrosopyrrolidine
N-Nitrosopyrrolidine (NPYR) is a hepatocarcinogen in rats. It is metabolically activated by cytochrome P450 enzymes in the liver leading to the formation of 4-oxobutanediazohydroxide (4) and related intermediates that react with DNA to form adducts. Since DNA adducts are thought to be critical in ca...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518975/ https://ncbi.nlm.nih.gov/pubmed/17394361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx600333e |
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