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Identification of Adducts Formed in the Reaction of α-Acetoxy-N-Nitrosopyrrolidine with Deoxyribonucleosides and DNA
N-Nitrosopyrrolidine (NPYR) is a well-established hepatocarcinogen in the rat. NPYR requires metabolic activation by cytochrome P450-catalyzed α-hydroxylation to express its carcinogenic activity. This produces α-hydroxyNPYR (2) which spontaneously ring opens to 4-oxobutanediazohydroxide (4), a high...
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| Glavni autori: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518840/ https://ncbi.nlm.nih.gov/pubmed/17394360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx600332p |
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