Detection and Quantitation of Acrolein-Derived 1,N(2)-Propanodeoxyguanosine Adducts in Human Lung by Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry

Acrolein, a widely distributed environmental pollutant, reacts with dGuo in DNA to form two pairs of 1,N(2)-propano-dGuo adducts: (6R/S)-3-(2′-deoxyribos-1′-yl)-5,6,7,8-tetrahydro-6-hydroxypyrimido[1,2-a]purine-10(3H)one (α-OH-Acr-dGuo) and (8R/S)-3-(2′-deoxyribos-1′-yl)-5,6,7,8-tetrahydro-8-hydroxy...

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Bibliographic Details
Main Authors: Zhang, Siyi, Villalta, Peter W., Wang, Mingyao, Hecht, Stephen S.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518976/
https://ncbi.nlm.nih.gov/pubmed/17385896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx700023z
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