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Detection and Quantitation of Acrolein-Derived 1,N(2)-Propanodeoxyguanosine Adducts in Human Lung by Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry
Acrolein, a widely distributed environmental pollutant, reacts with dGuo in DNA to form two pairs of 1,N(2)-propano-dGuo adducts: (6R/S)-3-(2′-deoxyribos-1′-yl)-5,6,7,8-tetrahydro-6-hydroxypyrimido[1,2-a]purine-10(3H)one (α-OH-Acr-dGuo) and (8R/S)-3-(2′-deoxyribos-1′-yl)-5,6,7,8-tetrahydro-8-hydroxy...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518976/ https://ncbi.nlm.nih.gov/pubmed/17385896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx700023z |
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