Nicotinamidase modulation of NAD(+) biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans

Nicotinamide adenine dinucleotide (NAD(+)) is a central molecule in cellular metabolism and an obligate co-substrate for NAD(+)-consuming enzymes, which regulate key biological processes such as longevity and stress responses. Although NAD(+) biosynthesis has been intensely studied, little analysis...

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Bibliographic Details
Main Authors: Vrablik, Tracy L., Huang, Li, Lange, Stephanie E., Hanna-Rose, Wendy
Format: Artigo
Language:Inglês
Published: Company of Biologists 2009
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761111/
https://ncbi.nlm.nih.gov/pubmed/19820182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.028431
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