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Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis Stemming from Lack of Salvage NAD(+) Biosynthesis Impairs Reproductive Development in Caenorhabditis elegans
Temporal developmental progression is highly coordinated in Caenorhabditis elegans. However, loss of nicotinamidase PNC-1 activity slows reproductive development, uncoupling it from its typical progression relative to the soma. Using LC/MS we demonstrate that pnc-1 mutants do not salvage the nicotin...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4646267/ https://ncbi.nlm.nih.gov/pubmed/26350462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662916 |
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